Tuesday, April 30, 2013

New drug stimulates immune system to kill infected cells in animal model of hepatitis B infection

New drug stimulates immune system to kill infected cells in animal model of hepatitis B infection

Monday, April 29, 2013

A novel drug developed by Gilead Sciences and tested in an animal model at the Texas Biomedical Research Institute in San Antonio suppresses hepatitis B virus infection by stimulating the immune system and inducing loss of infected cells.

In a study conducted at Texas Biomed's Southwest National Primate Research Center, researchers found that the immune modulator GS-9620, which targets a receptor on immune cells, reduced both the virus levels and the number of infected liver cells in chimpanzees chronically infected with hepatitis B virus (HBV). Chimpanzees are the only species other than humans that can be infected by HBV. Therefore, the results from this study were critical in moving the drug forward to human clinical trials which are now in progress.

The new report, co-authored by scientists from Texas Biomed and Gilead Sciences, appears in the May issue of Gastroenterology. Gilead researchers had previously demonstrated that the same therapy could induce a cure of hepatitis infection in woodchucks that were chronically infected with a virus similar to human HBV.

"This is an important proof-of-concept study demonstrating that the therapy stimulates the immune system to suppress the virus and eliminate infected liver cells," said co-author Robert E. Lanford, Ph.D., of Texas Biomed. "One of the key observations was that the therapy continued to suppress virus levels for months after therapy was stopped.

The current therapy for HBV infection targets the virus and works very well at suppressing viral replication and delaying progression of liver disease, but it is a lifelong therapy that does not provide a cure.

"This GS-9620 therapy represents the first conceptually new treatment for HBV in more than a decade, and combining it with the existing antiviral therapy could be transformative in dealing with this disease," stated Lanford.

The Gilead drug binds a receptor called Toll-Like Receptor 7 that is present in immune cells. The receptor normally recognizes invading viruses and triggers the immune system to suppress viral replication by the innate immune response and kill infected cells by the adaptive immune response, thus orchestrating both arms of the immune system.

HBV damages the liver, leading to cirrhosis and liver cancer. Liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer death. According to the United States Centers for Disease Control and Prevention (CDC), up to 1.4 million Americans are chronically infected with HBV.

The World Health Organization estimates that two billion people have been infected with the hepatitis B virus, resulting in more than 240 million people with chronic infections and 620,000 deaths every year.

###

Texas Biomedical Research Institute: http://txbiomed.org/

Thanks to Texas Biomedical Research Institute for this article.

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Source: http://www.labspaces.net/127969/New_drug_stimulates_immune_system_to_kill_infected_cells_in_animal_model_of_hepatitis_B_infection

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White House: Anthony Foxx in line for transportation post

WASHINGTON (AP) ? President Barack Obama on Monday will nominate Charlotte, N.C., Mayor Anthony Foxx as his new transportation secretary, a White House official said Sunday.

If confirmed by the Senate, Foxx would replace outgoing Secretary Ray LaHood.

Foxx is Obama's first black nominee among the new Cabinet members appointed for the second term. The president faced criticism early in his second term for a lack of diversity among his nominees.

The official insisted on anonymity to avoid public discussion of the pick before the official announcement.

The official noted that Foxx has led efforts to improve his city's transit infrastructure to expand economic opportunity for businesses and workers. During Foxx's term as mayor, Charlotte has broken ground on several important transportation projects, including the Charlotte Streetcar Project to bring modern electric tram service to the city as well as a third parallel runway at Charlotte/Douglas International Airport. The city has also moved to extend the LYNX light rail system to the University of North Carolina at Charlotte, the official said.

If confirmed by the Senate, Foxx would take over a department that has been at the center of Washington's debate over the impact of the so-called sequester cuts. The automatic cuts resulted in furloughs for air traffic controllers that helped cause delays at many airports.

Congress reached a deal last week to provide the Transportation Department flexibility that allowed it to end the air traffic controller furloughs.

Foxx, an attorney who has worked in several positions with the federal government, was first elected mayor in 2009. He raised his national profile last year when Charlotte played host to the Democratic Party's convention.

He also served as a member of the Charlotte City Council.

Source: http://news.yahoo.com/wh-anthony-foxx-line-transportation-post-211537174.html

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Monday, April 29, 2013

Lenovo IdeaCentre Q190


The Lenovo IdeaCentre Q190 ($399.99 list) is a compact Windows 8-equipped PC that can easily be tucked away behind your HDTV or monitor. Although its Intel Celeron 887 processor isn't the strongest performer, it's nonetheless a good value thanks to its bundled multimedia remote, modular slot-loading optical drive, and reasonable price tag. For users that don't plan on straying too far from its intended media purposes, it's a solid way to jazz up any home theatre system.


Design and Features
The IdeaCentre Q190's trim plastic chassis measures 0.86 by 7.55 by 6.10 inches (HWD). Even though its modular optical drive nearly doubles the system's thickness to 1.5 inches, the IdeaCentre Q190 nonetheless remains compact enough to maintain an inconspicuous presence behind an HDTV or monitor. Moreover, the IdeaCentre Q190's glossy black finish and silver accents lends the system a tastefully subdued aesthetic that won't force you to hide it out of embarrassment when you have company over. Four rubber feet on the system's underside provide a grip, though it ships with a bundled stand for vertical orientation as well as a VESA monitor mount.

Despite its small size, the IdeaCentre Q190 offers a decent amount of ports. A door on the front of the chassis conceals a pair of USB 3.0 ports, media card reader, and audio ports. The rear sports five USB 2.0 ports (two of which are occupied by the optical drive), an Ethernet port, HDMI, VGA, and an optical SPDIF audio port. While it earns points for including a DVD burner, the IdeaCentre Q190 isn't as future-proof as our current Editors' Choice for nettop PCs, the Acer Revo RL100-UR20P, whose usefulness for the next few years is virtually ensured by its integrated Blu-ray player.

Like both the Zotac Zbox Nano AD12 Plus and Zotac Zbox ID83 Plus, the IdeaCentre Q190 doesn't ship with a bundled keyboard or mouse. It does, however, come with the Lenovo Mini Wireless Keyboard N5901, a nifty multimedia remote that integrates a full QWERTY keyboard and trackball into a single unit. Although its compact shape and ergonomic design make this couch companion perfect for one-handed operation, you'll need to spring for an actual keyboard if you plan on typing for extended periods of time.

The IdeaCentre Q190's 500GB 5,400rpm hard drive comes with some preloaded software. This isn't entirely a bad thing, though, since it also means that there's an actual operating system on the IdeaCentre 190, something that's lacking in both the Zbox Nano AD12 Plus or Zbox ID83 Plus. In addition to the usual proprietary software (like a Lenovo Rescue utility, among others), the rest of the software comes in handy, like Cyberlink PowerDVD burning suite. Lenovo covers the IdeaCentre Q190 with a one-year warranty.

Performance
Lenovo IdeaCentre Q190 The IdeaCentre Q190's 1.5GHz Intel Celeron 887 processor and 4GB RAM unsurprisingly yielded modest scores on our benchmark tests, and its overall performance was roughly on par with that of its peers but not quite as robust as a full-fledged desktop like the Gateway SX2380-UR318. Its PCMark7 score of 1,560 points easily trumped the Lenovo IdeaCentre Q180 (1,013 points) while falling short of the Zbox ID83 Plus (1,855 points) and, to a larger extent, the Gateway SX2380-UR318 (2,056 points). Similarly, its Cinebench R11.5 score of 1.16 points surpassed the Acer RL100-UR20P (0.69 point) and Zbox Nano AD12 Plus (0.65 point), but still fell short of the class-leading Zbox ID83 Plus (2.52 points).

Lenovo IdeaCentre Q190

Since the IdeaCentre Q190 is intended primarily for media consumption, it doesn't excel when it comes to content creation. It completed our Handbrake video-encoding test in 3 minutes, which fell short of Zotac Zbox ID83 Plus (1:26). Moreover, it took a glacial 12 minutes 19 seconds to run through the dozen or so filters in our Photoshop CS6 test, or nearly twice as long as the Zotac Zbox ID83 Plus (6:39). Given its components, then, it didn't register as a major shock that the IdeaCentre Q190 couldn't run any of our gaming benchmark tests. Beyond its role as home-entertainment system, the IdeaCentre Q190 lacks the firepower to perform much beyond light daily tasks such as web browsing and casual social gaming.

The Lenovo IdeaCentre Q190 is a reasonably priced way to spice up your home theatre system and tinker around with Windows 8 on a big screen. Its shortcomings are overshadowed by its reasonable price tag, generous port selection, and bundled multimedia remote. Still these attributes aren't enough to unseat the Acer Revo RL100-UR20P from its current Editors' Choice status, especially given the latter's Blu-ray drive. If that doesn't rank too highly on your list of priorities, though, the IdeaCentre Q190 is worth checking out.

BENCHMARK TEST RESULTS:

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/UWlyiRGVzGY/0,2817,2418291,00.asp

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Friday, April 26, 2013

Scientists image nanoparticles in action

Apr. 25, 2013 ? The macroscopic effects of certain nanoparticles on human health have long been clear to the naked eye. What scientists have lacked is the ability to see the detailed movements of individual particles that give rise to those effects.

In a recently published study, scientists at the Virginia Tech Carilion Research Institute invented a technique for imaging nanoparticle dynamics with atomic resolution as these dynamics occur in a liquid environment. The results will allow, for the first time, the imaging of nanoscale processes, such as the engulfment of nanoparticles into cells.

"We were stunned to see the large-ranged mobility in such small objects," said Deborah Kelly, an assistant professor at the Virginia Tech Carilion Research Institute. "We now have a system to watch the behaviors of therapeutic nanoparticles at atomic resolution."

Nanoparticles are made of many materials and come in different shapes and sizes. In the new study, Kelly and her colleagues chose to make rod-shaped gold nanoparticles the stars of their new molecular movies. These nanoparticles, roughly the size of a virus, are used to treat various forms of cancer. Once injected, they accumulate in solid tumors. Infrared radiation is then used to heat them and destroy nearby cancerous cells.

To take an up-close look at the gold nanoparticles in action, the researchers made a vacuum-tight microfluidic chamber by pressing two silicon-nitride semiconductor chips together with a 150-nanometer spacer in between. The microchips contained transparent windows so the beam from a transmission electron microscope could pass through to create an atomic-scale image.

Using the new technique, the scientists created two types of visualizations. The first included pictures of individual nanoparticles' atomic structures at 100,000-times magnification -- the highest resolution images ever taken of nanoparticles in a liquid environment.

The second visualization was a movie captured at 23,000-times magnification that revealed the movements of a group of nanoparticles reacting to an electron beam, which mimics the effects of the infrared radiation used in cancer therapies.

In the movie, the gold nanoparticles can be seen surfing nanoscale tidal waves.

"The nanoparticles behaved like grains of sand being concentrated on a beach by crashing waves," said Kelly. "We think this behavior may be related to why the nanoparticles become concentrated in tumors. Our next experiment will be to insert a cancer cell to study the nanoparticles' therapeutic effects on tumors."

The team is also testing the resolution of the microfluidic system with other reagents and materials, bringing researchers one step closer to viewing live biological mechanisms in action at the highest levels of resolution possible.

The study appeared in the April 14 print edition of Chemical Communications in the article "Visualizing Nanoparticle Mobility in Liquid at Atomic Resolution," by Madeline Dukes, an applications scientist at Protochips Inc. in Raleigh, N.C.; Benjamin Jacobs, an applications scientist at Protochips; David Morgan, assistant manager of the Cryo-Transmission Electron Microscopy Facility at Indiana University Bloomington; Harshad Hegde, a computer scientist at the Virginia Tech Carilion Research Institute; and Kelly, who is also an assistant professor of biological sciences in the College of Science at Virginia Tech.

Video: http://research.vtc.vt.edu/videos/2013/apr/11/nanoparticles-action/

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The above story is reprinted from materials provided by Virginia Tech. The original article was written by Ken Kingery.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Madeline J. Dukes, Benjamin W. Jacobs, David G. Morgan, Harshad Hegde, Deborah F. Kelly. Visualizing nanoparticle mobility in liquid at atomic resolution. Chemical Communications, 2013; 49 (29): 3007 DOI: 10.1039/C3CC41136B

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/SJCcdpS4XPc/130425142436.htm

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Africa, Liberal Humanitarianism, and NATO's Anthropology | ZERO ...

[Many thanks to Dan Glazebrook for producing a review that gets to very the heart of this book, such that reading his review is an education in itself. This was reproduced from the UK's Ceasefire Magazine.]

A Libyan man stands on Sirte?s bombed fishing harbour. May 12, 2011.

A Libyan man stands on Sirte?s bombed fishing harbour. May 12, 2011.

Books | Review | Slouching Towards Sirte: NATO?s War on Libya and Africa by Maximilian Forte

In his Ceasefire review, Dan Glazebrook examines Maximilian Forte?s withering indictment of liberal humanitarianism and its collusion in imperialist designs on Africa, as seen in NATO?s Libya campaign of 2011.

Monday, April 22, 2013

The media has gone very quiet on Libya of late; clearly, liberal imperialists don?t like to dwell on their crimes. This is not surprising. The modus operandi of the humanitarian imperialist is not one of informed reflection, but only permanent outrage against leaders of the global South; besides, in the topsy-turvy world of liberal interventionism, the ?failure to act? is the only crime of which the West is capable. As Forte puts it, their moral code holds that ?If we do not act, we should be held responsible for the actions of others. When we do act, we should never be held responsible for our own actions.?

With Gaddafi dead, the hunt is on for a new hate figure on whom to spew venom (Assad, Jong-Un); far more satisfying than actually evaluating our own role in the creation of human misery. This is the colonial mentality of the liberal lynch mob.

For the governments that lead us into war, of course, it makes perfect sense that we do not stop to look back at the last invasion before impatiently demanding the next one ? if we realised, for example, that the 1999 bombing of Serbia? (the textbook ?humanitarian intervention?) actually facilitated the ethnic cleansing of Kosovo that it was supposedly designed to prevent, we might not be so ready to demand the same treatment for every other state that falls short of our illusory ideals.

That is why this book is so important. Thoroughly researched and impeccably referenced, it tells the story of the real aims and real consequences of the war on Libya in its historical perspective.

Its author, Maximilian Forte, is well placed to do so. A professor of social anthropology in Montreal, much of his writing and research in recent years has been dedicated to the new imperialism, and especially its ?humanitarian? cover. He was amongst the first to really expose violent racism within the Libyan insurrection, and its role in facilitating NATO?s goals in Africa, and has provided consistently excellent analyses of the media coverage surrounding the conflict.

One of the book?s accomplishments is its comprehensive demolition of the war?s supposed justifications. Forte shows us that there was no ?mass rape? committed by ?Gaddafi forces? ? as alleged by Susan Rice, Hillary Clinton, Luis Ocampo and others at the time, but later refuted by Amnesty International, the UN and even the US army itself.

Despite hysterical media reports, there was no evidence of aerial bombing of protesters, as even CIA chief Robert Gates admitted. Gaddafi had no massacre planned for Benghazi, as had been loudly proclaimed by the leaders of Britain, France and the USA: the Libyan government forces had not carried out massacres against civilian populations in any of the other towns they recaptured from the rebels, and nor had Gaddafi threatened to do so in Benghazi; in a speech that was almost universally misreported in the Western media, he promised no mercy for those who had taken up arms against the government, whilst offering amnesty for those who ?threw their weapons away?, and at no point threatening reprisals against civilians.

When the NATO invasion began, French jets actually bombed a small retreating column of Libyan armour on the outskirts of Benghazi, comprising 14 tanks, 20 armoured personnel carriers, and a few trucks and ambulances ? nothing like enough to carry out a ?genocide? against an entire city, as had been claimed.

Indeed, the whole image of ?peaceful protesters being massacred? was turning reality on its head. In fact, Forte notes, rebels ?torched police stations, broke into the compounds of security services, attacked government offices and torched vehicles? from the very start, to which the authorities responded with ?tear gas, water cannons and rubber bullets ? very similar to methods frequently used in Western nations against far more peaceful protests that lacked the element of sedition?. Only once the rebels had proceeded to occupy the Benghazi army barracks, loot its weapons, and start using them against government forces did things begin to escalate.

Myth of the Dark Heart

But the most pernicious of the lies that facilitated the Libyan war was the myth of the ?African mercenary?. Racist pogroms, Forte argues, were characteristic of the Libyan rebellion from its very inception, when 50 sub-Saharan African migrants were burnt alive in Al-Bayda on the second day of the insurgency. An Amnesty International report from September 2011 made it clear that this was no isolated incident: ?When al-Bayda, Beghazi, Derna, Misrata and other cities first fell under the control of the NTC in February, anti-Gaddafi forces carried out house raids, killing and other violent attacks? against sub-Saharan Africans and black Libyans, and ?what we are seeing in western Libya is a very similar pattern to what we have seen in Benghazi and Misrata after those cities fell to the rebels? ? arbitrary detention, torture and execution of black people.

The ?African mercenary? myth was thus created to justify these pogroms, as the Western media near-universally referred to their victims as ?mercenaries? ? or ?alleged mercenaries? in the more circumspect and highbrow outlets ? and thus as aggressors and legitimate targets. The myth was completely discredited by both Amnesty International ? whose exasperated researcher told a TV interviewer that ?We examined this issue in depth and found no evidence: the rebels spread these rumors everywhere [with] terrible consequences for African guest workers? ? and by a UN investigation team, who drew similar conclusions ? but not until both organisations had already helped perpetuate the lie themselves.

That liberal humanitarians would launch a war of aggression in order to facilitate racist massacres is not as ironic as it might at first seem. Forte writes that ?if this was humanitarianism, it could only be so by disqualifying Africans as members of humanity.? But such disqualification has been a systematic practice of liberalism from the days of John Locke, through the US war of independence and into the age of nineteenth century imperialism and beyond.

Indeed, Forte argues that the barely-veiled ?racial fear of mean African bogeymen swamping Libya like zombies? implicit in the ?African mercenary? story, was uniquely and precisely formulated to tap into a rich historical vein of European fantasies about plagues of black mobs. That the myth gained so much traction despite zero evidence, says Forte, ?tells us a great deal about the role of racial prejudice and propaganda in mobilizing public opinion in the West and organizing international relations?.

Yet the racism of the rebel fighters was not only useful for mobilising European public opinion ? it also played a strategic function, as far as NATO planners were concerned. By bringing to power a virulently anti-black government, the West has ensured that Libya?s trajectory as a pan-African state has been brought to a violent end, and that its oil wealth will no longer be used for African development. As Forte succinctly put it, ?the goal of US military intervention was to disrupt an emerging pattern of independence and a network of collaboration within Africa that would facilitate increased African self-reliance. This is at odds with the geostrategic and political economic ambitions of extra-continental European powers, namely the US?.

A large part of the book is dedicated to outlining Libya?s role in the creation of the African Union, and its subsequent moves to unify Africa at the economic, political and military levels. This included the investment of billions of petrodollars in industrial development across the continent, the creation of an African communications satellite, and massive financial contributions towards the African Development Bank and the African Monetary Fund ? institutions designed specifically to challenge the hegemony of the International Monetary Fund and the World Bank. Gaddafi, Forte argues, was passionate about using Libyan oil money to help Africa industrialise and ?add value? to its export materials, moving it away from its prescribed role in the global economy as a supplier of cheap raw materials.

A US-led Scramble for Africa

This was a threat to Western financial and corporate control of African economies, and combined with the rise of Chinese investment, was considered a strategic obstacle to Western domination that had to be removed. As Forte put it, ?The US, France and the UK could not afford to see allies that they had cultivated, if not installed in power, being slowly pulled from their orbits by Libya, China and other powers?.

The African Oil Policy initiative Group ? a high level US Committee comprising members of Congress, military officers and energy industry lobbyists ? noted in 2002 the growing dependence of the US on African oil, and recommended? a ?new and vigorous focus on US military cooperation in sub-Saharan Africa, to include design of a sub-unified command structure which could produce significant dividends in the protection of US investments?. They noted that ?failure to address the issue of focusing and maximizing US diplomatic and military command organization?could?act as an inadvertent incentive for US rivals such as China [and] adversaries such as Libya?. In other words, with their economic grip on the continent facing serious challenge, the Western world would increasingly have to rely on aggressive militarism in order to maintain its interests.

The recommendations of the committee would be implemented in 2006 with the creation of AFRICOM ? the US army?s African Command. AFRICOM was conceived as a sort of ?School of the Americas? for Africa, designed to train African armies for use as proxy forces for maintaining Western control, with the 2010 US National Security Strategy specifically naming the African Union as one of the regional organisations it sought to co-opt.

Libya, however, proved most uncooperative. The leaked US diplomatic cables make it very clear that Libya was viewed by the US as THE main obstacle to establishing a full muscular US military presence on the African continent, regularly highlighting its ?opposition? and ?obstruction? to AFRICOM. With Gaddafi still a respected voice within the AU, having served as its elected Chairman in 2009, he wielded significant influence, and used this to spearhead opposition to what he considered the neocolonial aims of the AFRICOM initiative.

Meanwhile, Chinese investment in Africa was growing rapidly, having grown from $6 billion in 1999 to $90 billion ten years later, displacing the US as the continent?s largest trading partner. The need for a US military presence to cling on to the West?s declining influence in Africa was growing ever more urgent. But Africa was not playing ball ? and Gaddafi was (rightly) seen as leading the charge.

Fast forward to 2012, and US General Carter Ham, head of AFRICOM, was able to claim that ?the conduct of military operations in Libya did afford now the opportunity to establish a military to military relationship with Libya, which did not previously exist?. He went on to suggest that a US base would be established in the country (Gaddafi having expelled both the US and British bases shortly after coming to power in 1969), saying that some ?assistance? would probably be necessary, in the form of a ?military presence?. President Obama wasted no time in announcing the deployment of soldiers to four more African countries within weeks of the fall of Tripoli, and AFRICOM announced an unprecedented 14 joint military exercises in Africa for the following year.

A sign of things to come

Forte argues that NATO?s attack had not only destroyed a powerful force for unity and independence in Africa, and a huge obstacle to Western military penetration of the continent, but it had also created the perfect conditions to justify further invasions. The US had previously attempted to argue that its military presence was required in North Africa in order to fight against Al Qaeda; indeed, it had set up the Trans-Saharan Counter Terrorism Programme to this end. But as Muattasim Gaddafi had explained to Hilary Clinton in Washington in 2009, the programme had been rendered redundant by the existing, and highly effective, security strategy of CEN-SAD (the Libyan-led Community of Sahel and Saharan states) and the North African Standby Force.

Like a classic protection racket, however, the British, US and French decided that if their protection wasn?t needed, then they would have to create a need for it. The destruction of Libya tore the heart out of the North African security system, flooded the region with weapons and turned Libya into an ungoverned safe haven for violent militias. Now the resulting ? and entirely predictable ? instability has spread to Mali, the West are using it as an excuse for another war and occupation. In a prescient warning (the book was published before France?s recent invasion of Mali), Forte wrote that ?intervention begets intervention. More intervention is needed to solve the problems caused by intervention.?

The book is also very strong in exposing the ideology of the ?human rights industry? and its role in bringing about the Libyan war. Western liberal humanitarianism, argues Forte, ?can only function by first directly or indirectly creating the suffering of others, and by then seeing every hand as an outstretched hand, pleading or welcoming?.

Forte goes on to expose the role of groups like Amnesty International and Human Rights Watch, who helped perpetuate some of the worst lies about what was happening in Libya, such as the fictitious ?African mercenaries? and ?mass rape?, and who in the case of Amnesty, ?mere days into the uprising and well before it had a chance to ascertain, corroborate or confirm any facts on the ground?began launching public accusations against Libya, the African Union and the UNSC for failing to take action?. By calling for an assets freeze on Libya and an arms embargo (?and more actions with each passing day?), Amnesty ?thus effectively made itself a party to the conflict?; it had become part of the propaganda war and mythmaking that was designed to facilitate the invasion.

This should not be surprising given Amnesty?s history. Forte helpfully recalls that their promotion of the infamous ?incubator babies? myth that justified the Iraq war of 1991 was later singled out by several US Senators as having influenced their decision to vote for the attack. In the event, the Senate vote was passed by a majority of just six. The 1991 war devastated Iraq, which had barely recovered from the Iran-Iraq war, killing well over 100,000 people, as well as hundreds of thousands more from the diseases that ravaged the country following the deliberate destruction of its water and sewerage systems.

So it should be little surprise that Suzanne Nossel, a State Department official on Hilary Clinton?s team, was made Executive Director of Amnesty-USA in November 2011. In her State Department job, Nossell had played a key role drawing up the UN Human Rights Council resolution against Libya that ultimately formed the basis for Security Council Resolution 1973 that led to the aggression.

Forte also discusses the role of Bouchuiguir, the ?human rights activist? who emerges as the Libyan ?Curveball?. Curveball was the Iraqi ?source? who came up with the lies about Saddam?s nonexistent ?mobile chemical weapons factories? that were used to justify the 2003 Iraq war. Likewise, Bouchuiguir?s wildly inflated casualty figures provided the raw material for the hysterical UNHRC resolutions against Libya that set the ball for war rolling. He later admitted on camera that there was no evidence for his claims ? but not before 70 NGOs had signed a petition ?demanding action? in response to them.

Much has been written elsewhere about the ?neo-cons? who became (rightly) hated for their brutally idiotic conceptions of social change. But, as Forte?s book shows, the liberal humanitarians are perhaps even more contemptible; after all, at least the neo-cons never claimed to be kind, or even interested in anything other than their own self-interest. Yet the liberal humanitarians seem ? or at least claim ? to be driven by some kind of higher purpose, which makes their constant calls for wars of aggression even more repulsive. Forte puts this brilliantly:

?The vision of our humanity that liberal imperialists entertain is one which constructs us as shrieking sacks of emotion. This is the elites? anthropology, one that views us as bags of nerve and muscle: throbbing with outrage, contracting with every story of ?incubator babies?, bulging up with animus at the arrest of Gay Girl in Damascus, recoiling at the sound of Viagra-fuelled mass rape. From mass hysteria in twitter to hundreds of thousands signing an online Avaaz petition calling for bombing Libya in the name of human rights, we become nerves of mass reaction?.We scream for action via ?social media?, thumbs furiously in action on our ?smart? phones. ..Then again, our ?action? merely consists of asking the supremely endowed military establishment to act in our name.?

This anthropology is of course ?accompanied by NATO?s implicit sociology: societies can be remade through a steady course of high altitude bombings and drone strikes.?

How exactly Libya has been remade is also discussed in the book. The July 2012 elections in Libya, their very existence trumpeted in Western media as immediately vindicating every act of butchery the war brought about ? regardless of whether the parliament being elected was likely to wield any actual influence over the country ? saw fewer than half the eligible voting population take part. Even more intriguing were the results of a survey carried out in Libya by Oxford Research International that found that only 13% of Libyans said they wanted democracy within a year?s time, and only 25% within five years.

Meanwhile, the new authorities set about persecuting their opponents, real and imagined. The town of Tawergha was emptied of its entire population of around 20,000 black Libyans after militias from Misrata began systematically torching every home and business in the town, with the support of the central government. Former residents now reside in refugee camps where they continue to be hunted down and killed, or in arbitrary detention in makeshift prisons. Candidacy for elections is barred to: workers (a professional qualification is needed); anyone who ever worked in any level of government between 1969 and 2011 (unless they could demonstrate ?early and clear? support for the insurrection); anyone with academic study involving Gaddafi?s Green book; and anyone who ever received any monetary benefit from Gaddafi.

A constitutional lawyer noted these restrictions would disqualify three quarters of the Libyan population. Other new laws banned the spreading of ?news reports, rumours or propaganda? that could ?cause any damage to the state?, with penalties of up to life in prison; and prison for anyone spreading information that ?could weaken the citizens? morale? or for anyone who ?attacks the February 17 revolution, denigrates Islam, the authority of the state or its institutions?.SLOUCHING TOWARDS SIRTE

This is the new Libya for which the human rights imperialists and their allies lobbied, killed and tortured so hard. ?The next time empire comes knocking in the name of human rights?, concludes Forte, ?please be found standing idly by?.

Forte?s? book is a must-read for anyone seriously interested in understanding the motives and consequences of the West?s onslaught against Libya and African development.

Slouching Towards Sirte: NATO?s War on Libya and Africa
Maximilian Forte
Paperback and E-book: 352 pages
Publisher: Baraka Books (November 28, 2012)

Dan Glazebrook is a teacher and journalist, with a particular interest in the military and economic relationships between the west and the global South.

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Source: http://zeroanthropology.net/2013/04/25/africa-liberal-humanitarianism-and-natos-anthropology/

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Justin Bieber Has How Many New Songs In His Journal?

Manager Scooter Braun tells MTV News about the music Biebs has penned during his Believe Tour.
By Jocelyn Vena


Justin Bieber
Photo: Chiaki Nozu/Getty Images

Source: http://www.mtv.com/news/articles/1706277/justin-bieber-journal-new-music.jhtml

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Safety Tips for Running Outdoors - Shape Magazine

Finally it?s starting to feel like spring. The warmer temps and longer daylight hours make this the perfect time of year to take your runs outdoors. While research shows that exercising in nature has lots of benefits for your mental and physical health, running outside also invites risks that you wouldn?t have to worry about on a treadmill. Stay safe as you soak in the warmer weather on your outdoors runs with these expert tips.

1. Run in well-lit, populated areas. ?Avoid environments that could make you a victim, like a deserted trail at dawn or dusk,? says Jean Knaack, executive director of the Road Runners Club of America. If you find yourself in an isolated area, be sure to take out your ear buds: Women in headphones appear to be easier targets to sexual predators.

2. Trust your gut?it?s usually right. If you see a suspicious person approaching you, give them as wide a berth on the street or path as possible. ?Don?t look down?keep your eyes on the person, but cross to the other side of the street if you can,? Knaack says. If there?s enough distance, consider turning in the opposite direction and running away as fast as you can, she adds.

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RELATED:?Stay injury-free and go faster by improving your running technique.

3. Put up a fight. ?If you?re approached, establish the impression that you?ll be a terrible victim: loud, fearless, and willing to fight,? says Lynne Marie Wanamaker, a certified personal trainer and self-defense instructor. Be verbally and physically assertive?look the person straight in the eye and speak loudly, saying, ?Stop right there,? ?You?re too close,? or ?Leave me alone.? An attacker is likely looking for someone who will be easy to overpower, not someone who?s willing to get physical.

4. Know basic self-defense skills. Be aware of the top four vulnerable spots on a person?s body: eyes, nose, throat, and knees. If you?re close enough to fight back, do it. ?Imagine the attacker is trying to hurt your mom, sister, or child, and fight just as dirty to protect yourself as you would to save another woman you love,? Wanamaker says. ?Plus, remember that self defense works. Studies show that fighting back correlates with reduced rates of rape and does not correspond with higher rates of physical injury.?

RELATED: Stay confident, strong, and safe by learning what every woman needs to know about self defense.

5. Always carry your smartphone. While mace and pepper spray can be effective if used properly, more often than not they?re left at home or zipped in a back pocket, rendering them useless in an emergency. But you still have a weapon: ?Your cell is a great self-defense tool,? Knaack says. Download these five handy apps today to help keep you safe on any outdoor adventure:

  • ReactMobile?enables you to report suspicious incidents or send your current GPS coordinates to pre-selected contacts with the push of a button if you?re approached.
  • StaySafe allows you to enter your expected running path and timing, and if you don?t check back within the allocated time, your pre-set emergency contacts will receive your GPS coordinates?even if your phone is switched off.
  • MyPanic?is a free app that lets you trigger?a piercing alarm and flash bright colors to grab the attention of other people who may be nearby.
  • Guardly?sends emergency alerts to your selected safety network, who will be informed of your real-time location and whether you?ve called 911.
  • bSafe turns your phone into the ultimate safety device. One touch of a button sounds a siren, records a video, alerts authorities, and informs selected contacts of your GPS location.

Source: http://www.shape.com/blogs/working-it-out/top-5-tips-safe-spring-runs

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White House formally notifies Congress of Japan free-trade talks

By Doug Palmer

WASHINGTON (Reuters) - President Barack Obama's administration on Wednesday notified Congress it will start free-trade talks with Japan, bringing the world's third-largest economy into U.S.-led negotiations on a regional free-trade pact.

"The participation of Japan, a major U.S. trading partner as well as close ally, further increases the economic significance of a TPP (Trans-Pacific Partnership) Agreement," acting U.S. Trade Representative Demetrios Marantis said in a letter to congressional leaders.

The 90-day notification was expected after U.S. and Japanese negotiators reached a deal on April 12 on the terms of Japan's entry into the TPP talks, which are now in their fourth year. It could clear the way for Japan to participate in the July round of TPP talks.

The United States and the 10 other countries already involved in the TPP talks on Saturday formally approved Japan's entry into the negotiations at a meeting of regional trade ministers in Indonesia.

Marantis sought to reassure lawmakers that Japan's participation would not slow down the TPP negotiations, which are slated for conclusion by the end of the year, and that Japan would not refuse to negotiate in sensitive agricultural and manufacturing sectors of interest to U.S. exporters.

"Japan has confirmed it will participate positively and constructively in the negotiations. Japan also confirmed that it will subject all goods to negotiations - both agricultural and manufactured goods - and will join with the other TPP countries to achieve a high-standard and comprehensive agreement this year," Marantis said.

The White House sees the TPP pact as part of its economic rebalancing toward Asia. It also plans to launch free-trade talks with the 27-nation European Union in coming months.

Countries around the world are moving increasingly toward regional free-trade agreements in the absence of any progress toward a comprehensive world trade deal.

Detroit-based auto makers, particularly Ford Motor Co, have lobbied against Japan joining the TPP talks.

They say the agreement will open the door for more imports from Japan, without tearing down barriers that they say keep U.S. autos out of Japan's market.

In addition to the United States and Japan, TPP countries include Australia, Brunei, Canada, Chile, Malaysia, Mexico, New Zealand, Peru, Singapore, and Vietnam.

The 17th round of TPP talks is scheduled for May 15-24 in Lima, Peru. It is expected to be followed by an 18th round sometime in July that could be the first time that Japan participates in the negotiations.

(Reporting by Doug Palmer; Editing by Sandra Maler and Mohammad Zargham)

Source: http://news.yahoo.com/white-house-formally-notifies-congress-japan-free-trade-202413960.html

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Wednesday, April 24, 2013

EE has lured 318,000 customers to 4G since launching five months ago (updated)

EE draws 318,000 3 percent  of its customers to 4G, says its on track

EE's just released its Q1 2013 earnings, giving us a look at its first full quarter with 4G services. The carrier says it's on track to its goal of a million 4G customers by the end of the year, thanks to the addition or migration of 318,000 LTE customers since the service launched.. Despite those more profitable clients, however, total service revenue (excluding hardware sales) was down 1.5 percent for the period over last quarter, to £1.42 billion. On one hand, the number of 4G additions could be seen as disappointing considering the company's strong marketing push of the service -- though on the other, the company's only just activated numerous regions, making that one million 4G subscriber goal seem more likely than not. We'll just have to wait a bit longer to see if Brits are really in love with LTE's extra zip -- and willing to pay for it.

Update: This article originally stated that EE added 318,000 4G customers in Q1 this year, but that figure actually represents the number of users the carrier has added since launching its 4G service. five months ago

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Source: EE

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ypSElsvWj_8/

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NY brothers' $5 million lottery theft trial starts

SYRACUSE, N.Y. (AP) -- Two brothers accused of stealing a winning $5 million scratch-off lottery ticket became agitated and angry when questioned about it, and one of them threatened to destroy it, a state lottery official testified Monday.

"I'll rip up this ticket right now," lottery division clerk Joan China quoted Nayel Ashkar as saying during a March 2012 interview.

China testified that Ashkar asked a lottery security investigator if he was accusing him of something.

The trial for Nayel Ashkar, 36, and Andy Ashkar, 34, began Monday in Onondaga County Court after the brothers signed waivers allowing Judge Joseph Fahey to rule from the bench.

Andy Ashkar is accused of stealing the ticket from Robert Miles at The Green Ale Market on Oct. 27, 2006. Prosecutors say Ashkar told Miles, a maintenance worker, the winning ticket was worth $5,000 and paid him $4,000 and kept the other $1,000 for the store, which his father owns.

Nayel Ashkar is accused of conspiring with his brother to try to claim the winnings just before the ticket expired. The jackpot was to be paid out over 20 years, not in a lump sum.

Prosecutor Beth Van Doren, in her opening statement, said the issue wasn't that the defendants waited so long to try to cash it.

"That is a legal right of the rightful owner," Van Doren said. "Robert Miles is the actual owner. Co-workers saw the elation, the devastation of Miles. He lost the ticket when Andy Ashkar snatched it from his hand."

Van Doren said the Ashkars made several conflicting statements to lottery officials and that led to an investigation and a recommendation not to pay the jackpot.

Defense attorney Robert Durr, who is representing Andy Ashkar, called the case one of "common sense" in his opening, saying the court would understand the delay in attempting to cash the ticket.

"There are major inconsistencies in what occurred that day," Durr said. "There is no way possible to find him guilty beyond a reasonable doubt."

Defense attorney Robert Tisdell, who represents Nayel Ashkar, said there was no evidence his client had committed any crime.

"Where's the proof?" Tisdell asked. "There's not been one witness, one claim, that ties him to the claim."

China, an employee of the lottery division for seven years, said the Ashkars drove to Schenectady to claim the prize instead of doing so at an office in Syracuse. She testified the brothers were expressionless and unable to give a definitive answer as to when the ticket was purchased.

China also said both initially declined to sign the necessary papers to claim the prize, adding that she had never experienced such a subdued reaction from a jackpot winner.

"I had never seen claimants come in that were unhappy. It's a life-changing event," China said. "They weren't excited. Andy wanted to know the process would be safe. He was worried about his parents."

China also testified that Nayel Ashkar asked if they could accept a smaller amount of money to avoid a media event.

The brothers' father, Nayef Ashkar, who was in the courtroom, is charged with conspiracy in the case. The father, who had declined to comment after his arrest, has a separate trial scheduled for September.

Source: http://news.yahoo.com/ny-brothers-5-million-lottery-124936965.html

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Twitter Takes On TV With Publicis Deal - Business Insider

Social Media Insights is a daily newsletter from Business Insider that collects and delivers the top social media news first thing every morning. You can sign up to receive Social Media Insights here or at the bottom of this post.


Twitter Secures Biggest Ad Deal Yet (Los Angeles Times)
Twitter has nailed its biggest advertising deal yet. The social media company has reached a deal with Publicis's Starcom MediaVest Group worth hundreds of millions of dollars over multiple years. The agreement is the first of its kind: a partnership between one of the largest buyers of advertising and Twitter. It comes as television networks prepare to woo advertisers with pricey presentations to showcase their fall prime-time schedules. It also heralds the arrival of Twitter as a must-have digital offering as more people visit social networking sites on mobile devices while watching TV. A recent study from Nielsen correlated increases in Twitter chatter with TV ratings. Read >

Does Social Sign-In Shift Signal Trouble For Facebook? (Marketing Pilgrim)
Social logins ? when you use your Facebook account to sign in to other apps???helps social media platforms like Facebook collect user data and increase their reach and ubiquity. Not surprisingly Facebook is the leader in this area but what is surprising is the inroads Google+ is making. Google now controls 34% of user social login preferences.?Read >

Why Developers Are Leaving The Facebook Platform (Andrew Chen)
Attitudes towards the Facebook platform have changed. So what happened? Here's why developers have increasingly ditched the Facebook platform:

  • Lack of virality
  • Higher ad rates
  • Constant retooling
  • Competition
  • The feed is finite
  • Mobile platforms are the new sexy opportunities

Can Facebook regain the excitement around the platform that they had years ago? Read >

How Does Facebook Affect TV Viewership? (CitizenNet via AllFacebook)
CitizenNet studied 77 television shows from 2011 and 2012, focusing on the time around season premieres, when interest in shows is usually at its highest. It studied more than 20 metrics provided by Facebook?s insights tool, comparing them with Nielsen viewership numbers using linear regression. Taking into account metrics such as click-through rate, people talking about shows, and other figures, CitizenNet came up with a value for predicted viewership. Facebook activity did lead to increased viewership. Read >

How To Build The Perfect Pinterest Profile (MarketingThink via Business2Community)
Use Pinterest for business as a picture-perfect addition to your digital and social media strategy. The Pinterest user base, which has recently reached 12 million, continues to grow, and it has become the fourth-largest Web traffic referral source behind Google, direct and Facebook. However, small businesses and enterprise software companies continue to challenge the utility of using Pinterest for business outside of marketing to women. Read >

Small Business Successes Using Social Media (Business2Community)
As a small business you may find you are very limited on funds and need to find affordable ways to market your business. One of the top choices these days is turning to the Internet and using social media. Read >

Source: http://www.businessinsider.com/twitter-takes-on-tv-with-publicis-deal-2013-4

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Tuesday, April 23, 2013

Join the Engadget HD Podcast live on Ustream at 8:30PM ET

Join the Engadget HD Podcast live on Ustream at 530PM ET

It's Monday, and you know what that means; another Engadget HD Podcast. We hope you will join us live when the Engadget HD podcast starts recording at 8:30PM. If you'll be joining us, be sure to go ahead and get ready by reviewing the list of topics after the break, then you'll be ready to participate in the live chat.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Em3YP8KGFU0/

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Monday, April 22, 2013

Felixstowe: Resort honours its outstanding sports stars - News ...

TOP shooter and Olympic judge Bill Bond has added another trophy to his burgeoning cabinet after being named as Felixstowe?s sports personality of the year.

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Mr Bond, a member of the Felixstowe Rifle Club, was one of a number of outstanding individual competitors, teams and officials honoured by the Felixstowe and District Council for Sport and Recreation.

Presenting the awards at the ceremony at Felixstowe Town Hall, mayor Mike Deacon praised the talents, skills, enthusiasm and commitment of the resort?s sports players ? from youngest to the oldest, and those behind the scenes working hard to ensure the town has the facilities needed and clubs keep running.

Sports council chairman, Michael Sharman said: ?We had some exceptional nominations this year and once again it was very hard to decide the winners with so much talent to choose from.

?There is a large number of people involved in a wide range of sports in Felixstowe and some great opportunities for people to get involved either competitively or in helping to organise clubs, and train and coach players.?

Lacey?s Fitness Sports Personality of the Year ? Bill Bond

Following three years of training, Bill qualified as an international judge and was selected as an official at all the Olympic shooting events for London 2012.

He was also a range officer for the 10m air gun and 50m rifle and pistol events at the Paralympics, overseeing all the shooting. He is now hoping to play a similar role at Rio 2016.

Bill won county titles for the individual shooting leagues for both 25 yards and 50m last year and was second in the 100yds, and runner-up in the county championship, having won it in 2011. He was first in the county senior championship for the second year running. He also won national and club titles.

Pierrot Stationers Junior Sports Personality of the Year ? Matthew Haskell

All-rounder Matthew had a superb season at several sports.

A member of Felixstowe Road Runners, the 14-year-old won his age class in an English School Athletics Association event and went onto represent Suffolk at Nottingham, where he came 13th out of 70.

He was top scorer for Felixstowe and Walton Utd under 14s A team, won best bowler for Felixstowe and Corinthians Youth Cricket Club, and a silver award with Felixstowe Waves swimming club.

Felixstowe Star Team of the Year ? Felixstowe and Corinthians Youth Cricket Club

In 2012, the club ? which has 100 boys and girls ? won four out of the five competitions it entered.

Its main triumph was in the cup in the Ipswich and District Youth League, ending a fantastic season with a 28 run win over Woolpit.

Eastcliff Carpets Club Official of the Year ? David Alford

David began playing for the Felixstowe Rugby Union Football Club back in 1985 when he was 18, making the first 15 three years later and holding a first team place until he was 36.

Since then he has spent time coaching junior players, as well as being a regular committee member and involved in many activities, including membership, organising sponsors for the club handbook and representing the club on the county committee.

Walton Barbers Service to Sport Award - Wendy Wootton

A member of Felixstowe Ferry Golf Club since 1996, Wendy has served as Lady Captain and has been junior organiser since 2004.

She has overseen several junior players progressing to single handicap, some of whom have represented the club at county, national and international competitions. Last year the juniors won two Suffolk team trophies.

She visits local schools with the club professional to introduce Tri-Golf to encourage children as young as five to take up golf, is the club?s director of marketing and membership, and organises an annual open day.

Source: http://www.ipswichstar.co.uk/news/felixstowe_resort_honours_its_outstanding_sports_stars_1_2022951

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A noninvasive avenue for Parkinson's disease gene therapy

A noninvasive avenue for Parkinson's disease gene therapy [ Back to EurekAlert! ] Public release date: 21-Apr-2013
[ | E-mail | Share Share ]

Contact: Jim Bernstein
jbernstein@aspet.org
301-646-3259
Federation of American Societies for Experimental Biology

BOSTON Researchers at Northeastern University in Boston have developed a gene therapy approach that may one day stop Parkinson's disease (PD) in it tracks, preventing disease progression and reversing its symptoms. The novelty of the approach lies in the nasal route of administration and nanoparticles containing a gene capable of rescuing dying neurons in the brain. Parkinson's is a devastating neurodegenerative disorder caused by the death of dopamine neurons in a key motor area of the brain, the substantia nigra (SN). Loss of these neurons leads to the characteristic tremor and slowed movements of PD, which get increasingly worse with time. Currently, more than 1% of the population over age 60 has PD and approximately 60,000 Americans are newly diagnosed every year. The available drugs on the market for PD mimic or replace the lost dopamine but do not get to the heart of the problem, which is the progressive loss of the dopamine neurons.

The focus of Dr. Barbara Waszczak's lab at Northeastern University in Boston is to find a way to harvest the potential of glial cell line-derived neurotrophic factor (GDNF) as a treatment for PD. GDNF is a protein known to nourish dopamine neurons by activating survival and growth-promoting pathways inside the cells. Not surprisingly, GDNF is able to protect dopamine neurons from injury and restore the function of damaged and dying neurons in many animal models of PD. However, the action of GDNF is limited by its inability to cross the blood-brain barrier (BBB), thus requiring direct surgical injection into the brain. To circumvent this problem, Waszczak's lab is investigating intranasal delivery as a way to bypass the BBB. Their previous work showed that intranasal delivery of GDNF protects dopamine neurons from damage by the neurotoxin, 6-hydroxydopamine (6-OHDA), a standard rat model of PD.

Taking this work a step further, Brendan Harmon, working in Waszczak's lab, has adapted the intranasal approach so that cells in the brain can continuously produce GDNF. His work utilized nanoparticles, developed by Copernicus Therapeutics, Inc., which are able to transfect brain cells with an expression plasmid carrying the gene for GDNF (pGDNF). When given intranasally to rats, these pGDNF nanoparticles increase GDNF production throughout the brain for long periods, avoiding the need for frequent re-dosing. Now, in new research presented on April 20 at 12:30 pm during Experimental Biology 2013 in Boston, MA, Harmon reports that intranasal administration of Copernicus' pGDNF nanoparticles results in GDNF expression sufficient to protect SN dopamine neurons in the 6-OHDA model of PD.

Waszczak and Harmon believe that intranasal delivery of Copernicus' nanoparticles may provide an effective and non-invasive means of GDNF gene therapy for PD, and an avenue for transporting other gene therapy vectors to the brain. This work, which was funded in part by the Michael J. Fox Foundation for Parkinson's Research and Northeastern University, has the potential to greatly expand treatment options for PD and many other central nervous system disorders.

###

To request an interview with Dr. Waszczak, please contact Jim Bernstein at the contact information listed above.

About Experimental Biology 2013

Experimental Biology's mission is to share the newest scientific concepts and research findings shaping future and current clinical advances and to give scientists and clinicians an unparalleled opportunity to hear from colleagues working on similar biomedical problems using different disciplines. With six sponsoring societies and another 20 U.S. and international guest societies, the annual meeting brings together scientists from throughout the United States and the world, representing dozens of scientific areas, from laboratory to translational to clinical research. The meeting also offers a wide spectrum of professional development sessions.

About the American Society for Pharmacology and Experimental Therapeutics

ASPET is a 5,100 member scientific society whose members conduct basic and clinical pharmacological research within the academic, industrial and government sectors. Our members discover and develop new medicines and therapeutic agents that fight existing and emerging diseases, as well as increase our knowledge regarding how therapeutics affects humans.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


A noninvasive avenue for Parkinson's disease gene therapy [ Back to EurekAlert! ] Public release date: 21-Apr-2013
[ | E-mail | Share Share ]

Contact: Jim Bernstein
jbernstein@aspet.org
301-646-3259
Federation of American Societies for Experimental Biology

BOSTON Researchers at Northeastern University in Boston have developed a gene therapy approach that may one day stop Parkinson's disease (PD) in it tracks, preventing disease progression and reversing its symptoms. The novelty of the approach lies in the nasal route of administration and nanoparticles containing a gene capable of rescuing dying neurons in the brain. Parkinson's is a devastating neurodegenerative disorder caused by the death of dopamine neurons in a key motor area of the brain, the substantia nigra (SN). Loss of these neurons leads to the characteristic tremor and slowed movements of PD, which get increasingly worse with time. Currently, more than 1% of the population over age 60 has PD and approximately 60,000 Americans are newly diagnosed every year. The available drugs on the market for PD mimic or replace the lost dopamine but do not get to the heart of the problem, which is the progressive loss of the dopamine neurons.

The focus of Dr. Barbara Waszczak's lab at Northeastern University in Boston is to find a way to harvest the potential of glial cell line-derived neurotrophic factor (GDNF) as a treatment for PD. GDNF is a protein known to nourish dopamine neurons by activating survival and growth-promoting pathways inside the cells. Not surprisingly, GDNF is able to protect dopamine neurons from injury and restore the function of damaged and dying neurons in many animal models of PD. However, the action of GDNF is limited by its inability to cross the blood-brain barrier (BBB), thus requiring direct surgical injection into the brain. To circumvent this problem, Waszczak's lab is investigating intranasal delivery as a way to bypass the BBB. Their previous work showed that intranasal delivery of GDNF protects dopamine neurons from damage by the neurotoxin, 6-hydroxydopamine (6-OHDA), a standard rat model of PD.

Taking this work a step further, Brendan Harmon, working in Waszczak's lab, has adapted the intranasal approach so that cells in the brain can continuously produce GDNF. His work utilized nanoparticles, developed by Copernicus Therapeutics, Inc., which are able to transfect brain cells with an expression plasmid carrying the gene for GDNF (pGDNF). When given intranasally to rats, these pGDNF nanoparticles increase GDNF production throughout the brain for long periods, avoiding the need for frequent re-dosing. Now, in new research presented on April 20 at 12:30 pm during Experimental Biology 2013 in Boston, MA, Harmon reports that intranasal administration of Copernicus' pGDNF nanoparticles results in GDNF expression sufficient to protect SN dopamine neurons in the 6-OHDA model of PD.

Waszczak and Harmon believe that intranasal delivery of Copernicus' nanoparticles may provide an effective and non-invasive means of GDNF gene therapy for PD, and an avenue for transporting other gene therapy vectors to the brain. This work, which was funded in part by the Michael J. Fox Foundation for Parkinson's Research and Northeastern University, has the potential to greatly expand treatment options for PD and many other central nervous system disorders.

###

To request an interview with Dr. Waszczak, please contact Jim Bernstein at the contact information listed above.

About Experimental Biology 2013

Experimental Biology's mission is to share the newest scientific concepts and research findings shaping future and current clinical advances and to give scientists and clinicians an unparalleled opportunity to hear from colleagues working on similar biomedical problems using different disciplines. With six sponsoring societies and another 20 U.S. and international guest societies, the annual meeting brings together scientists from throughout the United States and the world, representing dozens of scientific areas, from laboratory to translational to clinical research. The meeting also offers a wide spectrum of professional development sessions.

About the American Society for Pharmacology and Experimental Therapeutics

ASPET is a 5,100 member scientific society whose members conduct basic and clinical pharmacological research within the academic, industrial and government sectors. Our members discover and develop new medicines and therapeutic agents that fight existing and emerging diseases, as well as increase our knowledge regarding how therapeutics affects humans.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/foas-ana041813.php

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Pink Nintendo 3DS XL misses Easter, arrives in the UK later this Spring

Pink Nintendo 3DS XL misses Easter, arrives in the UK later this Spring

If the adorable patterns on the Animal Crossing special edition 3DS XL didn't tug at your heart (and wallet) strings, perhaps this English rose will. Set to arrive in the UK on May 31st, there's no software tie-in to mark the occasion, just the vivid hues of an entirely pink handheld. For the international purveyors of all things kawaii, there's still a pearl-finish pink and white 3DS XL listed on Amazon. Regardless of the shade, both options should pair really well with your vast collection of Hello Kitty tat goods.

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Source: Edge Online

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/h8tGykGyRZ0/

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Sunday, April 21, 2013

Jeptoo wins London Marathon amid high security

LONDON (AP) ? Priscah Jeptoo won the women's London Marathon amid strengthened security in the first major race since the twin bombings at the Boston race.

The London Olympics silver medalist, who like most competitors wore a black ribbon, crossed the line in front of Buckingham Palace in 2 hours 20 minutes, 15 seconds.

The Kenyan clocked the fastest time this year to finish ahead of compatriot Edna Kiplagat.

Source: http://news.yahoo.com/jeptoo-wins-london-marathon-amid-high-security-104426127--spt.html

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Investors brace for more stock volatility on Apple earnings

By Angela Moon and Doris Frankel

NEW YORK/CHICAGO (Reuters) - For years, Apple Inc was a stock investor's dream regardless of the market environment. But now concern about the iPhone maker's growth has made many investors wary about a big share swing after its earnings are released on Tuesday.

Options pricing on Friday suggested a post-earnings move of about 7.5 percent by April 26. That is far more than in the past and reflects the fact that Apple stock has become more volatile.

The company, once the world's largest by market value, saw its shares close below $400 on Thursday for the first time since December 2011. It has shed nearly $300 billion in market value since peaking at $705.07 a share in September.

"Being a bear on Apple used to be a lonely position. The tables have turned," said Enis Taner, global macro editor at options research firm RiskReversal.com in New York.

A 7.5 percent swing for Apple would be the fourth largest one-day post-earnings move in the last five years, according to research firm Birinyi Associates. That could take shares as high as $419.20 or as low as $360.80, based on the weekly $390 "straddle" expiring on April 26, which cost $29.20 on Friday.

Traders use prices on the straddle to estimate the market's view of the potential range of a stock going into an event such as earnings. A straddle combines the purchase of a call option and put option with the same strike price and expiration date.

A move of 7.5 percent would exceed the average move in Apple after its earnings, which in the last eight quarters has been 5.4 percent. Apple's biggest post-earnings swing was a 12.4 percent drop on January 23 of this year.

Apple is expected to report an 8 percent increase in quarterly revenue, among the weakest displays of quarterly growth in years, according to estimates. Earnings per share are expected to fall 18 percent as Samsung Electronics Co Ltd and other rivals erode market share for phones and tablets and put downward pressure on margins.

Because the stock was such a stalwart, investors for years knew it was difficult to go against the crowd. Between July 2009 and November 2012, short interest - the percentage of shares borrowed by investors who "short," or bet against, the stock - on Apple never exceeded two percent of the company's shares outstanding. At the current 2.1 percent, Apple's short interest is still lower than 55 percent of U.S. companies, according to Thomson Reuters Starmine.

Expectations of how much the stock is likely to move in coming weeks have also increased. Apple options show implied volatility for the next 30 days was 43.5 percent on Friday, according to data from options analytics firm Livevol.

That implies about a 4 percent move in the stock in either direction in the next month, said Livevol managing director Ophir Gottlieb.

Historic volatility for Apple for the 30-day period over the past year was about 34 percent. It has been rising over the past several months.

Many analysts still expect the stock to rebound because of still-strong demand for Apple's products. But there are many institutions that own shares bought at higher prices and they might remain a source of selling pressure if buyers surface, said Phil Erlanger, president of institutional research firm Phil Erlanger Research in Acton, Massachusetts.

"The problem for Apple is that those that have hung onto their shares after September will represent significant supply, which tends to squash any short-term advance," Erlanger said.

Apple is currently trading at nine times trailing earnings and 45 of 58 analysts polled by Reuters give the stock a "strong buy" or "buy" rating. According to Thomson Reuters Starmine, Apple's intrinsic value - a price target based on expected growth rates over the next decade - was about $565 a share.

The stock closed 0.4 percent lower on Friday at $390.53.

(Reporting By Angela Moon and Doris Frankel; Editing by David Gaffen and Andre Grenon)

Source: http://news.yahoo.com/investors-brace-more-stock-volatility-apple-earnings-111008330--finance.html

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